Nallsivam Palanisamy, M.Sc., M.Phil., Ph.D. (Genetics)
Assistant Research Professor
Michigan Center for Translational Pathology
Department of Pathology
University of Michigan Health System
University of Michigan Medical School
Comprehensive Cancer Center
University of Michigan
Ann Arbor, MI 48105
EDUCATION
1979-1981 University of Madras, Chennai, India, B.Sc Zoology
1981- 1983 University of Madras, Chennai, India, M.Sc Zoology
1983- 1984 University of Madras, Chennai, India, M.Phil Genetics
1985-1993 University of Madras, Chennai, India, Ph.D. Genetics
2009 MBAEE – MBA Essentials and Entrepreneurship
CURRENT PROFESSIONAL POSITION
8/2007-Present
Research Assistant Professor
Michigan Center for Translational Pathology
Department of Pathology
University of Michigan Medical School
University of Michigan Health System
Member, Comprehensive Cancer Center
University of Michigan
Ann Arbor, MI
EMPLOYMENT POSITIONS AND APPOINTMENTS
8/2007-8/2008
Consultant Molecular Cytogeneticist
Genome Institute of Singapore, Singapore
8/2005 – 8/2007
Adjunct Assistant Professor
School of Biological Sciences
Nanyang Technological University, Singapore
8/2004 – 8/2007
Group Leader, Cancer Biology, Genome Institute of Singapore
4/2000 – 7/2004
Director, Research & Development
Director, Genomics Research & Services
Cancer Genetics Inc., Milford, MA, USA
12/1999 - 3/2000
Senior Scientist, Research, & Development
Cancer Genetics Inc. Cambridge, MA, USA
1991-1993
Cytogeneticist, Institute of Laboratory Sciences
Kovai Medical Center and Hospital Ltd, Coimbatore, India
POSTDOCTORAL TRAINING
1990-1991
University of Vermont, Burlington, VT, USA
1993-1996
Miami Children's Hospital Research Institute, Miami, FL, USA
1996 –1999
Memorial Sloan-Kettering Cancer Center, New York City, NY, USA
MEMBERSHIP IN PROFESSIONAL SOCIETIES
1997-2004 Associate Member in American Society of Human Genetics (ASHG) USA
1997 Associate Member in American Association for Cancer Research (AACR) USA
2/2009 - Active Member in American Association for Cancer Research (AACR) USA (#15047)
2000 American Association for the Advancement of Sciences (AAAS), USA
Honors and Awards
1983 First Prize for Merit in M.Sc., Zoology (1983)
Kongunadu Arts and Science College, University of Madras
1985-1987 Junior Research Fellowships (JRF) Award
1987-1990 Senior Research Fellowship (SRF) Award, Council of Scientific and Industrial Research (CSIR), New Delhi, India.
2000-2003 Small Business Innovative Research (SBIR) Grant awards, funded by National Cancer Institute, National Institutes of Health-NIH USA. (Phase I 3; Phase II: 1)
2006 Agilent Technologies University Relations Grant Award
2009 The 2008 Singapore Medical Journal Best Reviewer Recognition Award
2009 Melanoma Research Alliance Development Award
2009 Agilent Technologies University Relations Grant Award
2009 Member, Comprehensive Cancer Center, University of Michigan, USA
JOURNAL REVIEW
Ad hoc Reviewer
Singapore Medical Journal – 2008 Best Reviewer Award
Biomed Central-Cancer
Cancer Research (AACR Journal)
Oncogene
Genetic Testing
COMMITTEE MEMBERSHIP
Advisory Board Member
International Conference on Biomarkers in Health and Environmental Management and XXXII Annual meeting of Environmental Mutagen Society of India. PSG College of Arts and Science, Coimbatore India. January 10-12, 2007
Advisory Board Member
International Conference on Toxic exposure related biomarkers, Genomes and Health Effects
NEERI Golden Jubilee Celebrations, 2007-2008 January 10-11, 2008, National Environmental Engineering Research Institute, Nehru Marg, Nagpur, 440020, India
Advisory Board Member
International Conference on Environment, Occupational and Lifestyle Concerns – Transdisciplinary Approach. 16-19 September 2009 Nirmal Bhawan, ROHCS-NIOH-ICMR Complex, Bangalore, INDIA
Member of the Board of Examiners
- PhD thesis evaluation Committee
Bharathiar University, Coimbatore, Tamilnadu, India
The Tamilnadu Dr.MGR Medical University, Tamilnadu India
National University of Singapore, Singapore
Grant Review Member - National Medical Research Council, Singapore
INVITED LECTURES
1989
Bharathiar University, Coimbatore, India, “Methods in Human Genetics,” Refresher course for College Teachers in Genetics
1992
Bharathiar University, Coimbatore, India. "Trends in Genetics,” Refresher Course for College Teachers in Botany
9/1997
Annual Conference of American Society for Bone and Mineral Research (ASBMR), Cincinnati, Ohio, USA September10-14, 1997. Novel chromosomal abnormalities in parathyroid adenomas identified by comparative genomic hybridization (CGH)
4/2001
Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Lymphoma Group: Biweekly Conference. April 25, 2001. A new portfolio of FISH probes for lymphoma and leukemia.
6/2002
Association of Genetic Technologists (AGT), 27th Annual Meeting, Cincinnati, Ohio, USA June 20-23 2002. New trends in translocation detection by Interphase FISH analysis
10/2002
Cancer Genetics Inc, Milford, MA, USA October 9, 2002. Workshop on Fluorescence in situ hybridization
6/2003
Association of Genetic Technologists (AGT), 28th Annual Meeting, Atlanta, GA, USA June
5-8 2008. Translocation detection and automated interphase FISH analysis.
7/2003
Genome Institute of Singapore, July 24, 2003. Recent trends in Molecular Cytogenetics.
3/2004
Memorial Sloan Kettering Cancer Center, New York, NY, USA March 13, 2004 “New Multicolor FISH probes” at workshop organized by Metasystems Group, MA.
6/2004
Association of Genetic Technologists (AGT), 29th Annual Meeting, Anaheim, CA, USA June 17-20, 2004. Translocation detection-multicolor approach
5/2005
School of Biological Sciences, Nanyang Technological University, Singapore. May 10 2005. Genes Chromosomes and Cancer – A cytogenetics perspective
6/2005
Association of Genetics Technologists (AGT), 30th Annual Meeting, Kansas City, Missouri, USA June 16-19, 2005, Translocation detection and automated interphase FISH analysis.
7/2005
Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India. Chief Guest, Inauguration of Zoology Association. Delivered special lecture on “Genes, Chromosomes, and Cancer – A Cytogenetics Perspective.” July 6, 2005
7/2005
BIOINFORMATICS INSTITUTE, BIOPOLIS, SINGAPORE, Cancer Cytogenetics – An overview, July 15, 2005
11/2005
“Translocation detection by Interphase FISH analysis” at the Workshop on Genes Chromosomes Cancer, organized by Research Instruments, Singapore, November 8, 2005. Biopolis Singapore
11/2005
‘Molecular Cytogenetics in Cancer Diagnostics’, invited speaker at the Health Worlds Asia 2005, An International Medical Congress, November 11-13, 2005, Biopolis Singapore.
4/2006
Understanding Genetics – Chromosome changes in Genetics Disorders. Singapore Science Center – Public Lecture April 22, 2006
5/2006
Unraveling the architecture of Tumor Genome. May 3, 2006. Agilent Technologies, Palo Alto, CA USA.
5/2006
Unraveling the Architecture of Cancer Genome – Department of Pathology, Public Lecture Series, National University Hospital, National University of Singapore, May 25, 2006
8/2006
Unraveling the architecture of tumor genome, Agilent Technologies- Singapore. Employees Coffee Talk Seminar Series. August 2006.
1/2007
“Oncogene Discovery through analysis of Genomic Imbalances” International Conference on Biomarkers in Health and Environmental Management and XXXII Annual meeting of Environmental Mutagen Society of India. PSG College of Arts and Science, Coimbatore January 10-12, 2007
1/2007
Understanding Genetics – Chromosome changes in genetic disorders, Cherraan’s College of Nursing and Pharmacy, Coimbatore India, January 12, 2007
1/2007
Oncogene discovery through analysis of Genomic Imbalances, Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA. January 17, 2007
3/2007
Unraveling the architecture of tumor genome” at the Indo-Australian Conference on “Human Variations and Pharmacogenomics” at Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India March 17-19, 2007.
8/2008
Integrative analysis of genomic imbalances in cancer. Midwest Microarray User Group Meeting August, 12-13, 2008 Chicago, IL
9/16/2008
Integrative analysis of genomic imbalances in cancer, Four Nation VIP Tour Seminar Series Organized and Sponsored by Agilent Technologies, USA. One-day seminar series along with local Scientists from Seoul National University Medical School, Seoul, Korea
9/17/2008
Integrative analysis of genomic imbalances in cancer, Four Nation VIP Tour Seminar Series Organized and Sponsored by Agilent Technologies, USA. One-day seminar series along with Scientists from Samsung Medical Center, Seoul, Korea
9/18/2008
Integrative analysis of genomic imbalances in cancer, Four Nation VIP Tour Seminar Series Organized and Sponsored by Agilent Technologies, USA. Beijing Oriental Hotel, Beijing, China
9/19/2008
Integrative analysis of genomic imbalances in cancer, Four Nation VIP Tour Seminar Series Organized and Sponsored by Agilent Technologies, USA. Shanghai Hope Hotel, Shanghai, China
9/22/2008
Integrative analysis of genomic imbalances in cancer, Four Nation VIP Tour Seminar Series Organized and Sponsored by Agilent Technologies, USA. One day seminar along with Scientists from A*STAR Institutes, Biopolis, Matrix Theaterette 4, Singapore
9/23/2008
Integrative analysis of genomic imbalances in cancer, Four Nation VIP Tour Seminar Series Organized and Sponsored by Agilent Technologies, USA. National Cancer Center, Singapore
9/25/2008
Integrative analysis of genomic imbalances in cancer, Four Nation VIP Tour Seminar Series Organized and Sponsored by Agilent Technologies, USA. Indian Institute of Science, Bangalore, India
9/26/2008
Integrative analysis of genomic imbalances in cancer, Four Nation VIP Tour Seminar Series Organized and Sponsored by Agilent Technologies, USA. Marriot Hotel, Hyderabad, India
4/22/2009
100th Annual American Association for Cancer Research Meeting, April 18-22, 2009 Colorado Convention Center, Denver, Colorado, USA Mini symposium- Functional Analysis of Cancer Genes and molecular markers Title: Analysis of genomic imbalances to detect gene fusions in cancer
8/19/2009
“a-CGH and its applications in Cancer” Midwest Microarray User Group meeting, Hyatt Regency, August 19-20, 2009 Chicago, IL USA
12/3/2009
Next Generation Sequencing – New Approaches to detect Gene Fusions in Cancer. ISAG2009: Medical Genome Science in the Personal Genome Era. International Symposium for applied genomics, Grand Arc Hanzomon in Tokyo, Japan. December 3rd and 4th, 2009
1/13/2010
“New approaches for the detection of gene fusions in cancer”. Center for Cancer Research and Therapeutic Development. Clark Atlanta University, January 14, 2010.
2/4/2010
“New approaches for the detection of gene fusions in cancer”. Medical University of South Carolina, February 4, 2010.
2/18/2010
Invited speaker at the International Conference in Cancer Biology: Molecular Mechanisms and Novel therapeutics. Indian Institute of Technology, Madras, India. February 18-20, 2010. Keynote address & Chaired a Session– “New approaches for the detection of gene fusions in cancer’. February 19, 2010.
6/19/2010
Genes, Chromosomes and Cancer. Indian Institute of Science Alumni Association of North America, Midwest Chapter. Third Annual Meeting, Saturday June 19, 2010, University of Michigan.
6/19/2010
Genes, Chromosomes and Cancer. Indian Institute of Science Alumni Association of North America, Midwest Chapter. Third Annual Meeting, Saturday June 19, 2010, University of Michigan.
8/4/2010
“Transcriptome sequencing to detect gene fusions in cancer”. Agilent Cytogenomics User Group Meeting, Hyatt Regency O’Hare, August 3-4, Chicago, IL.
11/16/2010
“Divide and conquer: Progress in the molecular stratification of prostate cancer”. United Kingdom Cancer Convention: Focus on Prostate. 16th November 2010, at RIBA (Royal Institute of British Architects), London.
WEB SEMINAR
“High-Resolution Analysis of Genomic Imbalances in the Cancer Genome”
http://agilent.cnpg.com/lsca/webinar/palanisamy/20080310/
COURSE
Attended 42nd Annual course in Medical and experimental mammalian genetics, July 16-27, 2001 at Jackson Laboratory co-organized with Johns Hopkins University, Bar Harbor, Maine, USA.
ABMG TRAINING
American Board of Medical Genetics training program in Clinical Cytogenetics: Memorial Sloan–Kettering Cancer center, New York, NY, USA. July 2000 – June 2002.
PATENTS GRANTED
United States Patent 7,585,964
Palanisamy , et al. September 8, 2009
Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH) Abstract: Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater selectivity and sensitivity; methods for producing such probes are also disclosed. The probe sets utilized in the detection methods are designed to hybridize to chromosomes at regions outside known breakpoints, instead of spanning the breakpoint as with conventional FISH methods, and, in some instances, are further designed to bind to regions located outside the genes involved in the rearrangement. Methods utilizing probe sets with two and four colors are also described, as are automated methods for analyzing rearrangements.
Inventors: Palanisamy, Nallasivam, Chaganti, Raju S.
PATENTS FILED
Provisional patent application submitted on May 14, 2001. Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH).
Inventors: Nallasivam Palanisamy and Raju Chaganti.
Institution: Cancer Genetics, Inc, USA
Provisional patent application submitted on November 8, 2001. Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH).
Inventors: Nallasivam Palanisamy and Raju Chaganti.
Institution: Cancer Genetics, Inc, USA
Patent application filed on April 5, 2005. Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH) United States Patent Application#: 20050214842.
Inventors: Nallasivam Palanisamy and Raju Chaganti.
Institution: Cancer Genetics, Inc, USA
Patent application filed on July 19, 2007. Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH). United States patent Application #: 20070166749.
Inventors: Nallasivam Palanisamy and Raju Chaganti
Institution: Cancer Genetics, Inc, USA
International application (No.PCT/ SG2007/000361) filed on 10/22/2007. Title: “Fused Genes.”
Inventors: Nallasivam Palanisamy, Kalpana Ramnarayanan, and Edison Liu, Genome Institute of Singapore, Singapore
Nallasivam Palanisamy
FUNDING FOR RESEARCH- PRINCIPAL INVESTIGATOR AWARDS
PI: Palanisamy, Nallasivam
5R44CA084838-04 - National Institutes of Health (NIH)
FISH ASSAY FOR THE DETECTION OF t(14; 18) (q32;q21)
Period: 12/01/00 – 5/31/04 US$ 996,693
PI: Palanisamy, Nallasivam
1R43CA089970-01- National Institutes of Health (NIH)
MOLECULAR PROBES FOR BURKITT’S AND MANTLE CELL LYMPHOMA
Period: 11/01/00 – 5/31/01 US$ 158,286
PI: Palanisamy, Nallasivam
1R43CA091532-01- National Institutes of Health (NIH)
FISH ASSAY FOR ACUTE MYELOID LEUKEMIA
Period: 11/01/2001 – 07/31/2002 US$ 233,250
PI: Palanisamy, Nallasivam
1R43CA094363-01- National Institutes of Health (NIH)
HIGH THROUGHPUT SYSTEM FOR FISH ANALYSIS
Period: 11/01/01 – 06/30/02 US$ 149,558
PI: Palanisamy, Nallasivam
Agilent Technologies, Research Project Grant Application
MOLECULAR CHARACTERIZATION OF BREAST CANCER GENOME
Period: May 2006 – April 2007 US$ 30,000
PI: Palanisamy, Nallasivam
Title: VALIDATION STUDIES IN SUPPORT OF THE DEVELOPMENT OF MULTI-PROBE FISH ASSAYS IN PROSTATE CANCER PARTNERS
Project Dates and Amount of Award: 01/01/10-03/31/10; $75,042
PI: Palanisamy, Nallasivam
Melanoma Research Alliance (Development Award)
TRANCRIPTOME SEQUENCING TO DETECT GENE FUSIONS IN MELANOMA
6/1/09-5/31/10 $50,000
PI: Palanisamy, Nallasivam
Combined use of aCGH and genome partitioning to identify and characterize recurrent genomic amplifications in prostate cancer: identification and sequence characterization of oncogenic and tumor suppressive events.
5/1/09-4/30/10 $48,537
PI: Palanisamy, Nallasivam
Title: Molecular profiling of ets gene rearrangement in prostate cancer patients registered in the redeem and reduce clinical trial.
03/12/10-08/31/10; $191,205
PI: Palanisamy, Nallasivam
University of Michigan, Comprehensive Cancer Center Summer Student Internship Award
Characterization of Gene Fusions in ETS negative prostate Cancer
May 2010-August 2010 - Award $5120
PENDING AWARDS
PI: Palanisamy, Nallasivam
1S10 RR031654-01 NIH – SHARED INSTRUMENTATION GRANT
HELICOS GENETIC ANALYSIS SYSTEM
Role: Principal Investigator
CO-INVESTIGATOR AWARDS
National Institutes of Health
FISH ASSAY FOR THE DETECTION OF t(14; 18) (q32;q21)
Period: 2/10/00 – 8/31/00 US$ 143,194
Role: Co-Investigator
R33 CA126966-01 PI: Prof. Edison T Liu
National Institute of Health (NIH)
PAIRED END DI TAG TECHNOLOGIES FOR THE COMPLETE ANNOTATION OF FUSION GENES
Period: February 2007- 2010 US$ 1,312,362
Role: Co-Investigator
Singapore Cancer Syndicate Programme Initiative 2007
Hardening the national xenograft therapeutic program: expansion of HCC xenograft infrastructure, drug evaluation, cell line generation and linkage to primary hccs via genomic analysis
Role: Co- Investigator PI: Dr. Huynh Hung Period: April 2007 – 3 years S$1,708,000
W81XWH-08-1-0031 (PI: Chinnaiyan) 04/15/08 – 07/14/11 0.84 cal mos
Department of Defense $121,746/yr
CHARACTERIZATION OF SPINK1 IN PROSTATE CANCER
Role: Co-Investigator
W81XWH-09-2-0014 (PI: Wicha) 03/01/09 – 04/24/11 3.0 cal mos
Department of Defense $350,000/yr directs
NATIONAL FUNCTIONAL GENOMICS CENTER
Role: Co-Investigator
W81XWH-08-0110 (PI: Chinnaiyan) 09/01/08 – 11/30/13 2.4 cal mos
Department of Defense $500,000/yr
A SEARCH FOR GENE FUSIONS/TRANSLOCATIONS IN BREAST CANCER
Role: Co-Investigator
2-R01-CA-107469-06-A1 (PI: Kleer) 07/01/10 – 04/30/15 0.6 cal mos
THE ROLE OF EZH2 IN BREAST CANCER PROGRESSION $278,389/yr
Role: Co-investigator
Mentorship – Undergraduate & Graduate students, Research Assistants, and Postdoctoral fellows
Mentorship– Undergraduate & Graduate students, Research Assistants, and
Postdoctoral fellows
Daphne Tan Research Assistant National University of Singapore
Ng Giok Lu Undergraduate Student Nanyang Technological University
Ho Jia Ying Agnes Undergraduate Student Nanyang Technological University
Vu Minh Tu Undergraduate Student Nanyang Technological University
Nyon Yit An Undergraduate Student Nanyang Technological University
Tan Wah Siew Grad Medical Student National University of Singapore
Wong Meng Kang Undergraduate Student National University of Singapore
Veena Goapalakrishnan Undergraduate Student National University of Singapore
William Lai Wee Thiam Teacher Anglo Chinese School, Singapore
Lee Pei Li Steffie Undergraduate Student Nanyang Polytechnic, Singapore
Lai Chooi Yan Anna Lois Junior College Student Raffles Junior College, Singapore
Chok Xiao Wei Undergraduate Student National University Singapore
Wong Han Teng High School Student Genome Institute of Singapore
Dkyaw Htet Hlaing Grad Medical Student Medical Student, Myanmar
Vasantha Priya Research Assistant Genome Institute of Singapore
Bangarusamy Dinothkumar Graduate Student Genome Institute of Singapore
Wilson Goh Graduate Student Genome Institute of Singapore
Dian Yan Polytechnic Student Nanyang Polytechnic, Singapore
Teoh Xuhui Junior College Student Raffles Junior College, Singapore
Poh Hui Yi Undergraduate Student Nanyang Tec.University, Singapore
Lim Ben Joo Jolin Undergraduate Student Nanyang Tec.University, Singapore
Du RJ Postdoctoral Fellow Genome Institute of Singapore
Phyllis Pereira Research Associate CancerGenetics Inc
Dolores Martinez Research Associate Cancer Genetics Inc
Katerina Dyomina Research Associate Cancer Genetics Inc
Bhuvaraghava Murthy Postdoctoral Fellow Cancer Genetics Inc
Penelope, Research Assistant Cancer Genetics Inc
Janice Kufel Research Associate Cancer Genetics Inc
Leanne Hoffman Research Assistant Cancer Genetics Inc
Paul Rooney Research Assistant Cancer Genetics Inc
Ian Jacob Bury Undergraduate student University of Michigan
Snigdha Gongati Reddy Undergraduate Student University of Michigan
Vaishnavi Premkumar Undergraduate Student University of Michigan
Sailaja Pullela Research Technician University of Michigan
Anjana Menon Research Technician University of Michigan
Lucy Lei Wang Research Technician University of Michigan
Kalpana Ramnarayanan Research Associate University of Michigan
Khalid Suleman Research Associate University of Michigan
Raj Jahirdar Research Associate University of Michigan
Santosh Shanmuga Undergraduate Student Duke University
Postdoctoral fellows
Daphne Tan Research Assistant National University of Singapore
Ng Giok Lu Undergraduate Student Nanyang Technological University
Ho Jia Ying Agnes Undergraduate Student Nanyang Technological University
Vu Minh Tu Undergraduate Student Nanyang Technological University
Nyon Yit An Undergraduate Student Nanyang Technological University
Tan Wah Siew Grad Medical Student National University of Singapore
Wong Meng Kang Undergraduate Student National University of Singapore
Veena Goapalakrishnan Undergraduate Student National University of Singapore
William Lai Wee Thiam Teacher Anglo Chinese School, Singapore
Lee Pei Li Steffie Undergraduate Student Nanyang Polytechnic, Singapore
Lai Chooi Yan Anna Lois Junior College Student Raffles Junior College, Singapore
Chok Xiao Wei Undergraduate Student National University Singapore
Wong Han Teng High School Student Genome Institute of Singapore
Dkyaw Htet Hlaing Grad Medical Student Medical Student, Myanmar
Vasantha Priya Research Assistant Genome Institute of Singapore
Bangarusamy Dinothkumar Graduate Student Genome Institute of Singapore
Wilson Goh Graduate Student Genome Institute of Singapore
Dian Yan Polytechnic Student Nanyang Polytechnic, Singapore
Teoh Xuhui Junior College Student Raffles Junior College, Singapore
Poh Hui Yi Undergraduate Student Nanyang Tec.University, Singapore
Lim Ben Joo Jolin Undergraduate Student Nanyang Tec.University, Singapore
Du RJ Postdoctoral Fellow Genome Institute of Singapore
Phyllis Pereira Research Associate CancerGenetics Inc
Dolores Martinez Research Associate Cancer Genetics Inc
Katerina Dyomina Research Associate Cancer Genetics Inc
Bhuvaraghava Murthy Postdoctoral Fellow Cancer Genetics Inc
Penelope, Research Assistant Cancer Genetics Inc
Janice Kufel Research Associate Cancer Genetics Inc
Leanne Hoffman Research Assistant Cancer Genetics Inc
Paul Rooney Research Assistant Cancer Genetics Inc
Ian Jacob Bury Undergraduate student University of Michigan
Snigdha Gongati Reddy Undergraduate Student University of Michigan
Vaishnavi Premkumar Undergraduate Student University of Michigan
Sailaja Pullela Research Technician University of Michigan
Anjana Menon Research Technician University of Michigan
Lucy Lei Wang Research Technician University of Michigan
Kalpana Ramnarayanan Research Associate University of Michigan
Khalid Suleman Research Associate University of Michigan
Raj Jahirdar Research Associate University of Michigan
Santosh Shanmuga Undergraduate Student Duke University
SPONSORED RESEARCH AWARDS (2) TOTAL: US$200,000
National Cancer Institute Subcontract (RFP-1108-17) between Bio-Reliance Corporation and Cancer Genetics, Inc. for Spectral Karyotyping (SKY), Fluorescence in situ hybridization (FISH) and G-band analysis on Waldenstrom macroglobulinemia (WM).
Role: Principal Project Director
Spectral Karyotyping (SKY), Comparative Genomic Hybridization (CGH), and Fluorescent in situ hybridization (FISH) analysis. July 1, 2001-May 27, 2002
National Cancer Institute Subcontract (RFP-1108-17- 2, 3) between Bio-Reliance Corporation and Cancer Genetics, Inc. for two projects
Role: Principal Project Director
Project 1. “Cytogenetic Biomarkers in Peripheral Blood Lymphocytes and Risk of Non-Hodgkin’s Lymphoma
Project 2. “A Cross-sectional Study of Occupational Exposure to Benzene and Un-banded Chromosomal Aberrations in Peripheral Blood Lymphocytes Among workers in China”.
Nallasivam Palanisamy
ARTICLES IN BOOKS AND OTHER MONOGRAPHS Personal Author (8)
Nallasivam Palanisamy, Marimuthu, KM, Prema L: A case of mosaic trisomy X and fragile site at 5q with congenital heart disease. Contemporary studies in Human Genetics, Ed. by S.B.Roy et.al, p-26-28, 1987
Nallasivam Palanisamy, Marimuthu KM, Prema L: Congenital heart disease in Down syndrome. Contemporary studies in Human Genetics, Ed. by SB.Roy et al., p-29-36, 1987
Nallasivam Palanisamy: Ring chromosome 3. A report of a case with features of Cornelia de -Lange syndrome. Genetics - Perspectives in Man and Environment. Ed. By ST Santhiya and G Jeyaraman, University of Madras, p-8-9, 1990
Nallasivam Palanisamy: Genetics of Congenital Heart Diseases. Ph.D. Thesis. University of Madras, Chennai, India. 1993
Nallasivam Palanisamy: Cytogenetics studies on selected heart diseases. M.Phil Thesis. University of Madras, Chennai, India. 1984
Gouri Nanjangud, Nallasivam Palanisamy, and R.S.K.Chaganti. Cytogenetic analysis and related techniques in hematopathology. In Diagnostic Hematopathology. Eds.Elaine S.Jaffe, Nancy Harris, James W. Wardiman, Elias Campo and Daniel A. Arber. Elsevier Inc. 2010.
Nallasivam Palanisamy. Chromosomal Translocations in AML: Detection and Prognostic Significance. Genetics, Biology and Therapy of Acute Myelogenous Leukemia,” (ed) Nagarajan L. In the Cancer Treatment and Research Series Springer-Verlag, 2010.
Nallasivam Palanisamy and Arul M. Chinnaiyan. “Chromosomal aberrations insolid tumors”. Progress in Molecular Biology and Translational Science (PMBTS),Vol.95 Edited by Raymond Ruddon. Editor-in-Chief: P. Michael Conn Elsevier Inc.2010. IN PRESS
Nallasivam Palanisamy- PUBLICATIONS
PEER REVIEWED PAPERS (44)
Yu J, Cao Q, Yu J, Wu L, Dallol A, Li J, Chen G, Grasso C, Cao X, Lonigro RJ, Varambally S, Mehra R, Palanisamy N, Wu JY, Latif F, Chinnaiyan AM. The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer. Oncogene. 2010 Jul 12. [Epub ahead of print]PMID: 20622896
Cytogenetic Evaluation of Down Syndrome:A Review of 1020 Referral Cases. N. Chandra, Cyrus Cyril, Prema Lakshminarayana, Nallasivam P, A. Ramesh, P. M. Gopinath and K. M. Marimuthu. Int J Hum Genet, 10(1-3): 87-93 (2010).
Palanisamy N, Ateeq B, Kalyana-Sundaram S, Pflueger D, Ramnarayanan K, Shankar S, Han B, Cao Q, Cao X, Suleman K, Kumar-Sinha C, Dhanasekaran SM, Chen YB, Esgueva R, Banerjee S, Lafargue CJ, Siddiqui J, Demichelis F, Moeller P, Bismar TA, Kuefer R, Fullen DR, Johnson TM, Greenson JK, Giordano TJ, Tan P, Tomlins SA, Varambally S, Rubin MA, Maher CA, Chinnaiyan AM. Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer, and melanoma. Nat Med. 2010 Jul;16(7):793-8. Epub 2010 Jun 6. PMID: 20526349
Palanisamy N. Chromosomal Translocations in AML: Detection and Prognostic Significance. Cancer Treat Res. 2009; 145:41-58. PMID: 20306244
Han B, Suleman K, Wang L, Siddiqui J, Sercia L, Magi-Galluzzi C, Palanisamy N, Chinnaiyan AM, Zhou M, Shah RB. ETS Gene Aberrations in Atypical Cribriform Lesions of the Prostate: Implications for the Distinction Between Intraductal Carcinoma of the Prostate and Cribriform High-grade Prostatic Intraepithelial Neoplasia. Am J Surg Pathol. 2010 Mar 8. [Epub ahead of print] PMID: 20220513
Mani RS, Tomlins SA, Callahan K, Ghosh A, Nyati MK, Varambally S, Palanisamy N, Chinnaiyan AM. Induced chromosomal proximity and gene fusions in prostate cancer. Science. 2009 Nov 27;326(5957):1230. Epub 2009 Oct 29.PMID: 19933109
Wang XS, Prensner JR, Chen G, Cao Q, Han B, Dhanasekaran SM, Ponnala R, Cao X, Varambally S, Thomas DG, Giordano TJ, Beer DG, Palanisamy N, Sartor MA, Omenn GS, Chinnaiyan AM. An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer. Nat Biotechnol. 2009 Nov; 27(11):1005-11. Epub 2009 Nov 1. PMID: 19881495
Zhang J, Liu X, Datta A, Govindarajan K, Tam WL, Han J, George J, Wong C, Ramnarayanan K, Phua TY, Leong WY, Chan YS, Palanisamy N, Liu ET, Karuturi KM, Lim B, Miller LD. RCP is a human breast cancer-promoting gene with Ras-activating function. J Clin Invest. 2009 Aug; 119(8):2171-83. doi: 10.1172/JCI37622. Epub 2009 Jul 20. PMID: 19620787
Maher CA, Palanisamy N, Brenner JC, Cao X, Kalyana-Sundaram S, Luo S, Khrebtukova I, Barrette TR, Grasso C, Yu J, Lonigro RJ, Schroth G, Kumar-Sinha C, Chinnaiyan AM. Chimeric transcript discovery by paired-end transcriptome sequencing. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12353-8. Epub 2009 Jul 10.PMID: 19592507
Han B, Mehra R, Suleman K, Tomlins SA, Wang L, Singhal N, Linetzky KA, Palanisamy N, Zhou M, Chinnaiyan AM, Shah RB. Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma. Mod Pathol. 2009 Sep;22(9):1176-85. Epub 2009 May 22.PMID: 19465903
Han B, Mehra R, Lonigro RJ, Wang L, Suleman K, Menon A, Palanisamy N, Tomlins SA, Chinnaiyan AM, Shah RB. Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression. Mod Pathol. 2009 Aug;22(8):1083-93. Epub 2009 May 1.PMID: 19407851
Vega VB, Cheung E, Palanisamy N, Sung WK. Inherent signals in sequencing-based Chromatin-ImmunoPrecipitation control libraries. PLoS One. 2009;4(4):e5241. Epub 2009 Apr 15.PMID: 19367334
Maher CA, Kumar-Sinha C, Cao X, Kalyana-Sundaram S, Han B, Jing X, Sam L, Barrette T, Palanisamy N, Chinnaiyan AM. Transcriptome sequencing to detect gene fusions in cancer. Nature. 2009 Mar 5;458(7234):97-101. Epub 2009 Jan 11.PMID: 19136943 Selected by Faculty of 1000 Biology under “ EXCEPTIONAL” category F1000 Factor 9.0 -http://f1000biology.com
Benoît Legrand, C.S. Chang, S.H. Ong, Soek-Ying Neo, Nallasivam Palanisamy. Automated identification of chromosome segments involved in translocations by combining spectral karyotyping and banding analysis. IEEE Transactions on Systems, Man & Cybernetics (Part A Systems & Humans), Vol. 38, No. 6, Nov 2008, pp 1374 – 1384.
Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science. 2008 Dec 12;322(5908):1695-9. Epub 2008 Nov 13.PMID: 19008416 Selected by Faculty of 1000 Biology under “ EXCEPTIONAL” category F1000 Factor 9.0 -http://f1000biology.com
Han B, Mehra R, Dhanasekaran SM, Yu J, Menon A, Lonigro RJ, Wang X, Gong Y, Wang L, Shankar S, Laxman B, Shah RB, Varambally S, Palanisamy N, Tomlins SA, Kumar-Sinha C, Chinnaiyan AM. A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer. Cancer Res. 2008 Sep 15;68(18):7629-37.PMID: 18794152
Poonepalli A, Banerjee B, Ramnarayanan K, Palanisamy N, Putti TC, Hande MP. Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer. Genes Chromosomes Cancer. 2008 Dec;47(12):1098-109.PMID: 18720522
Huynh H, Chow PK, Palanisamy N, Salto-Tellez M, Goh BC, Lee CK, Somani A, Lee HS, Kalpana R, Yu K, Tan PH, Wu J, Soong R, Lee MH, Hor H, Soo KC, Toh HC, Tan P. Bevacizumab, and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Hepatol. 2008 Jul; 49(1):52-60. Epub 2008 Apr 28. PMID: 18490075
Benoît Legrand, C S Chang, S.H. Ong, Soek-Ying Neo, Nallasivam Palanisamy. Chromosome Classification Using Dynamic Time Warping. Pattern Recognition Letters 2008, 29, 215-222
Lin CY, Vega VB, Thomsen JS, Zhang T, Kong SL, Xie M, Chiu KP, Lipovich L, Barnett DH, Stossi F, Yeo A, George J, Kuznetsov VA, Lee YK, Charn TH, Palanisamy N, Miller LD, Cheung E, Katzenellenbogen BS, Ruan Y, Bourque G, Wei CL, Liu ET. Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet. 2007 Jun;3(6):e87. Epub 2007 Apr 17. PMID: 17542648
Ruan Y, Ooi HS, Choo SW, Chiu KP, Zhao XD, Srinivasan KG, Yao F, Choo CY, Liu J, Ariyaratne P, Bin WG, Kuznetsov VA, Shahab A, Sung WK, Bourque G, Palanisamy N, Wei CL. Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs). Genome Res. 2007 Jun;17(6):828-38. PMID: 17568001.
Zeng J, Du J, Zhao Y, Palanisamy N, Wang S. Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells. Stem Cells. 2007 Apr;25(4):1055-61. PMID: 17420229
Chen W, Salto-Tellez M, Palanisamy N, Ganesan K, Hou Q, Tan LK, Sii LH, Ito K, Tan B, Wu J, Tay A, Tan KC, Ang E, Tan BK, Tan PH, Ito Y, Tan P. Targets of genome copy number reduction in primary breast cancers identified by integrative genomics. Genes Chromosomes Cancer. 2007 Mar;46(3):288-301.PMID: 17171680
Lian Q, Lye E, Suan Yeo K, Khia Way Tan E, Salto-Tellez M, Liu TM, Palanisamy N, El Oakley RM, Lee EH, Lim B, Lim SK. Derivation of clinically compliant MSCs from CD105+, CD24- differentiated human ESCs. Stem Cells. 2007 Feb;25(2):425-36. Epub 2006 Oct 19. PMID: 17053208
Heselmeyer-Haddad K, Sommerfeld K, White NM, Chaudhri N, Morrison LE, Palanisamy N, Wang ZY, Auer G, Steinberg W, Ried T. Genomic Amplification of the Human Telomerase Gene (TERC) in Pap Smears Predicts the Development of Cervical Cancer. Am J Pathol. 2005 Apr; 166(4):1229-38. PMID: 15793301
Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H, Haas OA, Chaganti RS. Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32). Oncogene. 2004 Sep 9;23(41):6991-6. PMID: 15273723
Houldsworth J, Olshen AB, Cattoretti G, Donnelly GB, Teruya-Feldstein J, Qin J, Palanisamy N, Shen Y, Dyomina K, Petlakh M, Pan Q, Zelenetz AD, Dalla-Favera R, Chaganti RS. Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas. Blood. 2004 Mar 1;103(5):1862-8. Epub 2003 Nov 13. PMID: 14615382
Costa J, Shattuck TM, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RSK, Arnold, A. Mutational analyses of connexin 26, connexin 30 and connexin 46 as candidate tumor suppressor genes in parathyroid carcinoma. J Endocr Genet 3:57-62 2002.
Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A. Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma. Clin Endocrinol (Oxf). 2003 Aug;59(2):180-9. PMID: 12864795
Butler MP, Iida S, Capello D, Rossi D, Rao PH, Nallasivam P, Louie DC, Chaganti S, Au T, Gascoyne RD, Gaidano G, Chaganti RS, Dalla-Favera R. Alternative translocation breakpoint cluster region 5' to BCL-6 in B-cell non-Hodgkin's lymphoma. Cancer Res. 2002 Jul 15;62(14):4089-94. PMID: 12124346
Dyomin VG, Chaganti SR, Dyomina K, Palanisamy N, Murty VV, Dalla-Favera R, Chaganti RS. BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function. Genomics. 2002 Aug;80(2):158-65. PMID: 12160729
Imanishi Y, Tahara H, Palanisamy N, Spitalny S, Salusky IB, Goodman W, Brandi ML, Drüeke TB, Sarfati E, Ureña P, Chaganti RS, Arnold A.Clonal chromosomal defects in the molecular pathogenesis of refractory hyperparathyroidism of uremia. J Am Soc Nephrol. 2002 Jun;13(6):1490-8. PMID: 12039978
Palanisamy N, Abou-Elella AA, Chaganti SR, Houldsworth J, Offit K, Louie DC, Terayu-Feldstein J, Cigudosa JC, Rao PH, Sanger WG, Weisenburger DD, Chaganti RS. Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphoma. Genes Chromosomes Cancer. 2002 Feb;33(2):114-22. PMID: 11793437
Chen W, Palanisamy N, Schmidt H, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Houldsworth J, Chaganti RS. Deregulation of FCGR2B expression by 1q21 rearrangements in follicular lymphomas. Oncogene. 2001 Nov 15;20(52):7686-93.PMID: 11753646
Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Immunity. 2001 Mar;14(3):277-89. PMID: 11290337
Dyomin VG, Palanisamy N, Lloyd KO, Dyomina K, Jhanwar SC, Houldsworth J, Chaganti RS.MUC1 is activated in a B-cell lymphoma by the t(1;14)(q21;q32) translocation and is rearranged and amplified in B-cell lymphoma subsets. Blood. 2000 Apr 15;95(8):2666-71. PMID: 10753849
Brown SB, Brierley TT, Palanisamy N, Salusky IB, Goodman W, Brandi ML, Drüeke TB, Sarfati E, Ureña P, Chaganti RS, Pike JW, Arnold A. Vitamin D receptor as a candidate tumor-suppressor gene in severe hyperparathyroidism of uremia. J Clin Endocrinol Metab. 2000 Feb;85(2):868-72. PMID: 10690903
Edelmann L, Pandita RK, Spiteri E, Funke B, Goldberg R, Palanisamy N, Chaganti RS, Magenis E, Shprintzen RJ, Morrow BE.A common molecular basis for rearrangement disorders on chromosome 22q11.Hum Mol Genet. 1999 Jul;8(7):1157-67.PMID: 10369860
Rao PH, Houldsworth J, Palanisamy N, Murty VV, Reuter VE, Motzer RJ, Bosl GJ, Chaganti RS. Chromosomal amplification is associated with cisplatin resistance of human male germ cell tumors. Cancer Res. 1998 Oct 1;58(19):4260-3. PMID: 9766648
Palanisamy N, Imanishi Y, Rao PH, Tahara H, Chaganti RS, Arnold A. Novel chromosomal abnormalities identified by comparative genomic hybridization in parathyroid adenomas. J Clin Endocrinol Metab. 1998 May;83(5):1766-70. PMID: 9589690
Selvakumar A, Steffens U, Palanisamy N, Chaganti RS, Dupont B.Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103.Tissue Antigens. 1997 Jun;49(6):564-73. PMID: 9234477
Iida S, Rao PH, Nallasivam P, Hibshoosh H, Butler M, Louie DC, Dyomin V, Ohno H, Chaganti RS, Dalla-Favera R. The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood. 1996 Dec 1;88(11):4110-7. PMID: 8943844
Aikawa M, Palanisamy N, Kuro-o M, Kimura K, Nakahara K, Takewaki S, Ueda M, Yamaguchi H, Yazaki Y, Periasamy M, Ryozo Nagai. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res. 1993 Dec; 73(6):1000-12. PMID: 7916668
Lakshminarayana P, Nallasivam P. Cornelia de Lange syndrome with ring chromosome 3. J Med Genet. 1990 Jun;27(6):405-6. PMID: 2359108
Nallasivam Palanisamy -
ABSTRACTS PRESENTED AT INTERNATIONAL MEETINGS/CONFERENCES
Prema L, Palanisamy N, Marimuthu KM: Congenital heart disease in Down syndrome-A report of 1042 cases. National Down syndrome Congress, Hyderabad, India, 1987
Prema L, Chandra, N, Palanisamy N, Marimuthu KM: Genealogy of translocation Down syndrome in Tamilnadu. National Down syndrome Congress, Hyderabad, India, 1987
Palanisamy N, Prema L, Marimuthu KM: Skeletal cardiovascular abnormalities in Holt Oram syndrome. Proceedings of the abstracts of the National Symposium on HLA in Human Genetics and XIII Annual Conference of Indian Society of Human Genetics, 26-28, October, 1987, Madurai, India, 1987
Palanisamy N, Marimuthu KM: Cytogenetic studies on congenital heart diseases: Increased karyotypic abnormality in Madras population (India). Genome 30.Suppl.1.p-32, 1988
Palanisamy N, Marimuthu KM: Role of biological mutagens in development-Congenital rubella syndrome. International symposium on Nature of genetic variations in Man. Hyderabad, India, 1988
Palanisamy N, Marimuthu KM: Partial trisomy 21 (dup (21) (pter-q21). Further evidence that trisomy of band 21q22 is essential for the manifestation of Down syndrome phenotype. XV th Annual Conference of Indian Society of Human Genetics. Madras, India. 1989
Matalon R, Kaul R, Aloya M, Jin M, Stoiloff S, Palanisamy N, Balamurugan K, Michals K: Carrier rate of Canavan disease among Ashkenazi Jewish Individuals. Fifth Annual Miami Children's Hospital Research Institute Symposium, December 5-7, 1994
Matalon R, Kaul R, Aloya M, Jin M, Stoiloff S, Palanisamy N, Balamurugan K, Michals K, and Levy PS: Canavan disease: Carrier rate of 1/36 among Ashkenazi Jews. Pediatric Research. 37(4) Part 2, Abstract # 887, 1994 PEDIATRIC RESEARCH Volume: 37 Issue: 4 Pages: A150-A150 Published: 1995 105th Annual Meeting of the American Pediatric Society and the 64th Annual Meeting of the Society for Pediatric Research, Date: May 7-11, 1995 San Diego, California,USA Pediatric Research Volume: 37 Issue: 4 PART 2 Pages: 150A Published: 1994
Palanisamy N, Chaganti RSK, and Arnold A: Novel chromosomal abnormalities in parathyroid adenomas identified by comparative genomic hybridization (CGH). Annual Conference of American Society for Bone and Mineral Research (ASBMR), Cincinnati, Ohio.September10-14, 1997. (ABSTRACT SELECTED FOR STAGE PRESENTATION, Speaker: Nallasivam Palanisamy, Ph.D.) JOURNAL OF BONE AND MINERAL RESEARCH Volume: 12 Pages: 159-159 Supplement: 1 Published: AUG 1997
Palanisamy N, Rao P H, Abou-Elella A, Weisenburger D D, Chaganti RSK: Comparison of primary mediastinal large B-cell and diffuse large cell lymphomas: Genetic anomalies defined by CGH. 39th Annual Meeting of the American Society of Hematology. SanDiego, California, December, 5-9, 1997 Blood Volume: 90 Issue: 10 SUPPL. 1 PART 1 Pages: 78A Published: Nov. 15, 1997
Palanisamy N, Tahara H, Imanishi Y, Salusky I, Goodman W, Brandi ML, Drueke TB, Sarfati E, Urena P, Chaganti RSK, Arnold A: Novel clonal chromosomal defects identified by comparative genomic hybridization and molecular allelotyping in refractory hyperparathyroidism of uremia. Annual Conference of American Society of Bone and Mineral research, San Francisco, December 1-5, 1998
Brown S B, Pike J W, Palanisamy N, Salusky I, Goodman W, Brandi ML, Drueke TB, Sarfati E, Urena P, Delmonico F, Chaganti RSK, Arnold A: Vitamin D receptor as a candidate tumor suppressor gene in severe hyperparathyroidism of uremia. Annual Conference of American Society of Bone and Mineral research, San Francisco, California, USA, December 1-5, 1998
Imanishi Y, Palanisamy N, Tahara H, Vickery A, Cryns VL, Gaz RD, Shoback D, Clark O, Monchik J, Wierman M, Hollenberg A, Tojo K, Chaganti RSK, Arnold A: Molecular pathogenetic analysis of parathyroid carcinoma. Annual Conference of American Society of Bone and Mineral research, St.Louis, Missouri, USA, September 30-October 4, 1999 JOURNAL OF BONE AND MINERAL RESEARCH Volume: 14 Pages: S421-S421 Supplement: 1 Published: SEP 1999 Meeting Abstract: SA446
Selvakumar A, Vyas Y, Steffens U, Palanisamy N, Chaganti RSK, Dupont B: Genomic organization of two killer cell immunoglobulin-like receptor genes encoding KIR3DL1 molecules with three IG-domains. 25th Annual Meeting of the American Society for Histocompatibility and Immunogenetics, New Orleans, LA October 20-24, 1999 Human Immunology Volume: 60 Issue: SUPPL. 2 Pages: S147 Published: 1999.
Schmidt HH, Dyomin V, Palanisamy N, Rao PH, Nanjangud G, Pirc-Danoewinata H, Hass OA, Chaganti RSK: Molecular cloning of a t(12;14)(q23;q32) translocation breakpoint from a case of chronic lymphocytic leukemia. 91st Annual Meeting of American Association for Cancer Research, San Francisco, CA, USA, April 1-5, 2000
Vadim Dyomin, Palanisamy N, Pulivarthi H Rao, Katerina Dyomina, Suresh C Jhanwar, Jane Houldsworth, RSK Chaganti: MUC1 is activated by t(1;14)(q21;q32) translocation in B-cell lymphomas. 91st Annual Meeting of American Association for Cancer Research, San Francisco, CA, USA, April 1-5, 2000
Chen Weiyi, Palanisamy N, Schmidt H, Chaganti S, Chaganti RSK: Molecular cloning of a novel gene involving translocation t(1;14)(q21;q32) in a low grade lymphoma. 91st Annual Meeting of American Association for Cancer Research, San Francisco, CA, USA, April 1-5, 2000 Proceedings of the American Association for Cancer Research Annual Meeting Issue: 41 Pages: 694 Published: March, 2000
Schmidt HH, Dyomin V, Palanisamy N, Rao PH, Nanjangud G, Pirc-Danoewinata H, Hass OA, Chaganti RSK. Dysregulation of the chondroitin 4-0-sulfotransferase 1 (C4ST-1) gene by a t (12; 14) (q23; q32) in a case of B-cell chronic lymphocytic leukemia (B-Cell). 42nd Annual Meeting of American Society of hematology, San Francisco, CA, USA December 1-5, 2000 (# 4404)
Ira J.Miller, Georgia Hatzivassiliou, Jun Takizawa, Giorgio Cattoretti, Rao Pulivarthi, Nallasivam Palanisamy, Shinsuke Lida, Shinichi Tagawa, James Russo, Cathy Mendelsohn, Raphael Clynes, Antonio Neri, R S K Chaganti, Riccardo Dalla-Favera. IRTAs: A new family of Fc-related cell surface receptors epressed in B cells and implicated in lymphomagenesis. 42nd Annual Meeting of American Society of hematology, San Francisco, CA, USA December 1-5, 2000 (#2149)
V. Dyomin, W. Chen, N. Palanisamy, K. Lloyd, K. Dyomina, S. Jhanwar, J. Houldsworth, R.S.K. Chaganti. Cloning of two t (1; 14) (q21; q32) translocation breakpoints common in Non-Hodgkin's Lymphomas that resulting in aberrant expression of MUC1 and FCGRIIB gene. Report of the Sixth International Workshop on Human Chromosome 1 Mapping 2000. University of Iowa College of Medicine, September 30–October 3, 2000
Mies C, Palanisamy N, Chaganti R S K. DNA gains and losses in lobular carcinoma in situ (LCIS) detected by comparative genomic hybridization (CGH). US & Canadian Academy of pathology meeting in Atlanta in March 2001
Helmut H. Schmidt, Vadim Dyomin, Nallasivam Palanisamy, Gouri Nanjangud, Hendrati Pirc-Danoewinata, Oskar A. Haas, Raju S. K. Chaganti. Deregulation of the Chondroitin-4-O-Sulfotransferase 1 (C4ST1) Gene by a t (12; 14) (q23; q32) in a Case of B-Cell Chronic Lymphocytic Leukemia. 92nd Annual Meeting of the American Association for Cancer Research. New Orleans, Lousiana, March 23- 2001
Palanisamy N, RSK, Chaganti. Novel fluorescent in situ hybridization (FISH) probe for simultaneous detection of t (9; 22) (q34; q11) and associated deletions on der (9) and der (22) chromosomes. 43rd Annual Meeting of the American Society of Hematology, December 7-11, 2001 Orlando, Florida. USA.
Trisha M. Shattuck, Teresa S. Kim, Jessica Costa, David Yandell, Yasuo Imanishi, Nallasivam Palanisamy, Randall D. Gaz, Dolores Shoback, Orlo Clark, John Monchik, Margaret Wierman, Anthony Hollenberg, Katsuyoshi Tojo, R.S.K. Chaganti, Andrew Arnold. Investigation of Rb and BRCA2 as candidate tumor suppressor genes in parathyroid carcinoma. 84th Annual meeting of the Endocrine Society, June 19-22, 2002 San Francisco, California, USA.
Palanisamy N and R S K Chaganti. Highly sensitive four-color fluorescent in situ hybridization assay for simultaneous detection of t (9; 22) (q34.1; q11.2) translocation and associated deletions on der (9) and der (22) Chromosomes. 93rd Annual Meeting of American Association for Cancer Research, April 6-10, 2002, San Francisco, California, USA.
Fu, K, Palanisamy N, Sanger WG, Chan WC, Greiner TC, Aoun P, Chaganti RSK, Weisenburger, DD. Recurrent genomic alterations in splenic marginal zone B-cell lymphoma. 92nd Annual meeting of the United States and Canadian academy of pathology, March 22-28, 2003, Marriott Wardman Park, Washington, DC.USA.
Huynh Hung, Patrick Tan, Nallasivam Palanisamy, Manual Salto-Tellez, Boon Goh, Khee Soo, Puay Tan, Richie Soong, Han Toh and Pierce Chow. Effective inhibition of tumor growth in patient-derived xenografts of hepatocellular carcinoma by rapamycin and bevacizumab. 98th AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA
Xiaosong Wang, Mohan Dhanasekaran, Nameeta Shah, John Liu, Bo Han, Alex Ade, Lihshwu Ke, Fan Meng, Rohit Mehra, Nallasivam Palanisamy, Gilbert S. Omenn, Arul Chinnaiyan. Genomic-Scale Screening for Gene Fusions in Human Solid Tumors by Integrative Biomedical Informatics. 3rd Annual Research Conference, National center for Integrative biomedical informatics, April 29-30, 2008. University of Michigan, Ann Arbor, USA.
Mohamed Hamza, Sebastian Pott, Vinsensius B Vega, Jane S. Thomsen, Gopalan Kandhadayar, Patrick NG, Nallasivam Palanisamy, Kuo Ping Chiu, Chia Lin Wei, Yijun Ruan and Edison Liu PPARg/RXR transcriptional circuitry governing adipocyte biology.. First AACR Centennial Conference on Translational Cancer Medicine-- Nov 4-8, 2007; Singapore
Bo Han, Rohit Mehra, Nallasivam Palanisamy, Khalid Suleman, Ming Zhou, Arul M. Chinnaiyan, Rajal B. Shah. Comprehensive assessment of TMPRSS2 and ETS family molecular aberrations in histologic variants of prostate carcinoma.
Rohit Mehra, MD, Scott A. Tomlins, PhD; Nallasivam Palanisamy, PhD; Rajal B. Shah, MD; Arul M. Chinnaiyan, MD, PhD. Fusion of ETS Family Members With Distinct 5′ Partners Typify a Unique Set of Gene Rearrangements in Prostate Cancer (Poster No. 17). Abstracts and Case Studies from the College of American Pathologists 2008 Annual Meeting (CAP '08) September 25-28, 2008 San Diego.
Bo Han, Rohit Mehra, Saravana M. Dhanasekaran, Jindan Yu, Anjana Menon, Robert J. Lonigro,
Xiaosong Wang, Yusong Gong, Lei Wang, Sunita Shanker, Bharathi Laxman, Rajal B Shah, Sooryanarayana Varambally, Nallasivam Palanisamy, Scott A Tomlins, Chandan Kumar-Sinha, Arul M Chinnaiyan. Comprehensive analysis of ETS family aberrations and characterization of novel gene fusions in prostate cancer. 7th Annual Pathology Research Symposium, The University of Michigan Medical School, Graduate Program in Molecular and Cellular Pathology, October 17, 2008 and University of Michigan Cancer Center Research Symposium, November 14, 2008.
Christopher A. Maher, Chandan Kumar-Sinha, Xuhong Cao, Shanker Kalyana-Sundaram, Bo Han, Lee Sam, Terrence Barrette, Nallasivam Palanisamy, Arul Chinnaiyan. Trascriptome sequencing to detect gene fusions in cancer. 7th Annual Pathology Research Symposium, The University of Michigan Medical School, Graduate Program in Molecular and Cellular Pathology, October 17, 2008 and University of Michigan Cancer Center Research Symposium, November 14, 2008.
Qi Cao, Sooryanarayana Varambally, Ram-Shankar Mani, Sunita Shankar,Xiaosong Wang, Bushra Ateeq, Bharathi Laxman, J. Chad Brenner, Jung H. Kim,Xuhong Cao, Bo Han, Patrick Tan, Chandan Kumar-Sinha, Nallasivam Palanisamy, Robert J. Lonigro, Christopher A. Maher and Arul M. Chinnaiyan. Genomic Loss of miR-101 Leads to Overexpression of EZH2 in Cancer. 7th Annual Pathology Research Symposium, The University of Michigan Medical School, Graduate Program in Molecular and Cellular Pathology, October 17, 2008 and University of Michigan Cancer Center Research Symposium, November 14, 2008.
Qi Cao, Sooryanarayana Varambally, Ram-Shankar Mani, Sunita Shankar, Xiaosong Wang, Bushra Ateeq, Bharathi Laxman, J. Chad Brenner, Jung Kim, Xuhong Cao, Bo Han, Chandan Kumar-Sinha, Patrick Tan, Nallasivam Palanisamy, Robert Lonigro, Christopher Maher and Arul Chinnaiyan. Genomic loss of a microRNA leads to overexpression of EZH2 in cancer. Cancer Prev Res 2008; 1(7 Suppl):B90. Abstract B90:
Rohit Mehra, MD, Bo Han, MD; Scott A. Tomlins, PhD; Nallasivam Palanisamy, PhD; Rajal B. Shah, MD; Arul M. Chinnaiyan, MD, PhD. Fusion of ETS Family Members With Distinct 5′ Partners Typify a Unique Set of Gene Rearrangements in Prostate Cancer (Poster No. 17) Archives of Pathology and Laboratory Medicine: Vol. 132, No. 9, pp. 1454–1527. Abstracts and Case Studies from the College of American Pathologists 2008 Annual Meeting (CAP '08)
Perner S, Pflueger D, Rickman DS, Lafargue CJ, Svensson MA, Demichelis F, Stephan C, Dietel M, Fritzsche FR, Han B, Palanisamy N, Mehra R, Allory Y, Maille P, De La Taille A, Kuefer R, Tewari AK, Chinnaiyan AM, Kristiansen G, Rubin MA EUROPEAN UROLOGY SUPPLEMENTS Volume: 8 Issue: 4 Pages: 317-317 Published: MAR 2009.
Role of microRNA-101 in regulating histone methyltransferase EZH2 in cancer Qi Cao, Sooryanarayana Varambally, Ram-Shankar Mani, Sunita Shankar, Xiaosong Wang, Bushra Ateeq, Bharathi Laxman, Xuhong Cao, Kalpana Ramnarayanan, Xiaojun Jing, J. Chad Brenner, Jindan Yu, Jung Kim, Bo Han, Patrick Tan, Chandan Kumar-Sinha, Robert Lonigro, Nallasivam Palanisamy, Christopher Maher, Arul Chinnaiyan. The University of Michigan, Ann Arbor, MI, National Cancer Centre, Singapore and Genome Institute of Singapore, Singapore, Singapore. Poster Session: Transcription Factors. 100th Annual American Association for Cancer Research Meeting 2009, April 18-22, 2009 Colorado Convention Center, Denver, Colorado.
Integrative transcriptome sequencing for discovery of gene fusions in prostate cancer Christopher A. Maher, Chandan Kumar-Sinha, Xuhong Cao, Shanker Kalyana-Sundaram, Bo Han, Xiaojun Jing, Lee Sam, Terrence Barrette, Nallasivam Palanisamy, Arul M. Chinnaiyan. Michigan Center for Translational Pathology, Ann Arbor, MI Minisymposium Understanding and Targeting Oncogenic Pathways 100th Annual American Association for Cancer Research Meeting 2009, April 18-22, 2009 Colorado Convention Center, Denver, Colorado.
Genomic-scale screening for gene fusions in human solid tumors by integrative biomedical informatics Xiaosong Wang, Saravana M. Dhanasekaran, John Presener, Bo Han, Nallasivam Palanisamy, Gilbert S. Omenn, Arul M. Chinnaiyan. Michigan Center for Translational Pathology; National Center for Integrative Biomedical Informatics and Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI Poster Session Cancer Informatics 2. 100th Annual American Association for Cancer Research Meeting 2009, April 18-22, 2009 Colorado Convention Center, Denver, Colorado.
The Role of TMPRSS2: ETS gene fusions in androgen independent metastatic prostate cancers Rohit Mehra, Scott Tomlins, Bo Han, Khalid Suleman, Xuhong Cao, Nallasivam Palanisamy, Anjana Menon, Lei Wang, Rajal B. Shah, Kenneth J. Pienta, Arul M. Chinnaiyan. Univ. of Michigan, Ann Arbor, MI Poster Session Novel Technologies in Cancer Biomarkers 100th Annual American Association for Cancer Research Meeting 2009, April 18-22, 2009 Colorado Convention Center, Denver, Colorado.
Analysis of genomic imbalances to detect gene fusions in cancer. Nallasivam Palanisamy, Kalpana Ramnarayanan, Thomas Choudary Putti, Kyew Htet Hlaing, Ram Shanker Mani, Chandan Kumar Sinha, Sooryanarayana Varambally, Patrick Tan, Arul Chinnaiyan. Mini-symposium Functional Analysis of Cancer Genes and molecular markers 100th Annual American Association for Cancer Research Meeting 2009, April 18-22, 2009 Colorado Convention Center, Denver, Colorado.
FISH SCREENING REVEALS RECURRENT ETV1 AMPLIFICATION IN MELANOMA. Kim S, Mohan D, Arul C, Douglas F, Mehra R, Bo H, Nallasivam P JOURNAL OF CUTANEOUS PATHOLOGY. Volume: 36 Issue: 1 Pages: 140-140 Published: JAN 2009
Utility of Qdot labeled FISH probes for detecting ETS gene rearrangements in prostate cancer.
Ubaradka Sathyanarayana, Christopher Lafargue, Dea Nagy, Janice Riley, Mark Bachrach, Raquel Esgueva, Ashley Santa-Cruz, Nallasivam Palanisamy, Raymond Nagle, Mark A. Rubin, Francesca Demichelis, Phillip Miller, Gary Pestano. 2010 Annual Meeting United States and Canadian Academy of Pathology March 20-26, 2010 Washington, DC.
An integrative approach to reveal driver gene fusions from paired end sequencing data in cancer. Xiaosong Wang, John R. Prensner, Guoan Chen, Qi Cao, Bo Han, Saravana M. Dhanasekaran, Rakesh Ponnala, David G. Beer, Nallasivam Palanisamy, Maureen Sartor, Gilbert S. Omenn, Arul M. Chinnaiyan. AACR 101st Annual Meeting 2010, April 17-21, 2010 Walter E. Washington Convention Center Washington DC, USA.
The role of chromosome architecture in the generation of gene fusions in prostate cancerRam S. Mani, Scott A. Tomlins, Kaitlin Callahan, Aparna Ghosh, Mukesh K. Nyati, Sooryanarayana Varambally, Nallasivam Palanisamy, Arul M. Chinnaiyan. AACR 101st Annual Meeting 2010, April 17-21, 20101 Walter E. Washington Convention Center Washington DC, USA.
Highly sensitive quantum dot fluorescence in situ hybridization for the detection of multiple gene rearrangements in prostate cancer. C. C. Cortez, M. Svensson, A. Santa-Cruz, K. Garsha, U. G. Sathyanarayana, N. Palanisamy, F. Demichelis, M. A. Rubin, P. Miller, G. Pestano. ASCO NCI EORTC Annual Meeting on Molecular Markers in Cancer (October 18 20, 2010).
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