Publication in Advanced Materials

Adv Mater. 2016 Apr 26. doi: 10.1002/adma.201600658. [Epub ahead of print]

Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells.

Yoon HJ1,2,3,4, Shanker A3,5, Wang Y1,3,4, Kozminsky M1,3,4, Jin Q1, Palanisamy N6, Burness ML7, Azizi E7, Simeone DM4,7, Wicha MS3,4,7, Kim J1,3,5,8,Nagrath S1,3,4.

Author information

Abstract

This study presents a highly sensitive microfluidic system to capture circulating tumor cells from the whole blood of cancer patients. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS:

breast cancer; circulating tumor cell; graphene oxide; pancreatic cancer; thermoresponsive polymer

PMID:

 

27115557

 

[PubMed - as supplied by publisher]