At the Intersection of Primary Pulmonary Myxoid Sarcoma and Pulmonary Angiomatoid Fibrous Histiocytoma: Observations from Three New Cases.
Twin recent reports identify a novel entity, primary pulmonary myxoid sarcoma (PPMS) and an endobronchial presentation of angiomatoid fibrous histiocytoma (AFH) . PPMS was described as 2-4cm lesions occurring in young patients (mean age 45 years), as endobronchial, lobulated neoplasms of polygonal to spindled cells within a myxoid stroma evocative of extraskeletal myxoid chondrosaroma (EMC) . In contrast to EMC, seven of nine testable cases harbored EWSR1-CREB1 gene fusions. Nine of ten showed remarkable associated inflammation, focal to follicular to lymphoplasmacytic. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS: FISH , angiomatoid fibrous histiocytoma, primary pulmonary myxoid sarcoma
PMID:24372335 [PubMed - as supplied by publisher]
